This research was a descriptive statistic (frequency, mean score, and standard deviation) and inferential statistic (independent sample t-test). The research showed that seventh grade students’ of SMPN 18 Makassar vocabulary mastery improve by using E-Mind Map Application by the increase of mean score of experimental class that is 42.7 classified as poor, in the pre-test and 80.7 classified as very good in the post test. The result of the t-test also showed that E-Mind Map Application was effective for the students’ vocabulary improvement because the t-test value was 4.115 higher than t-table value was 2.000 (4.115>>>> > 2.000). Based on the result of this research, it can be concluded that E-Mind Map Application is effective for the students’ vocabulary at VII grade students of SMPN 18 Makassar and there is significant difference between the students’ vocabulary mastery before and after using E-Mind Map Application.